GLS1 Inhibitor-4 manufacturers
- GLS1 Inhibitor-4
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- $2500.00
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2026-04-20
- CAS:2768599-97-7
- Purity:
- Supply Ability: 10g
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| | GLS1 Inhibitor-4 Basic information |
| Product Name: | GLS1 Inhibitor-4 | | Synonyms: | GLS1 Inhibitor-4;1H-Imidazole-2-carboxamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-1-[[4-(trifluoromethyl)phenyl]methyl]- | | CAS: | 2768599-97-7 | | MF: | C29H27F3N10O2S2 | | MW: | 668.72 | | EINECS: | | | Product Categories: | | | Mol File: | 2768599-97-7.mol |  |
| | GLS1 Inhibitor-4 Chemical Properties |
| density | 1.577±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 7.889±0.10(predicted) |
| | GLS1 Inhibitor-4 Usage And Synthesis |
| Uses | GLS1 Inhibitor-4 (compound 41e) is a potent GLS1 inhibitor with an IC50 of 11.86 nM. GLS1 Inhibitor-4 shows antiproliferative activity, good metabolic stability, robust GLS1 binding affinity. GLS1 Inhibitor-4 blocks the glutamine metabolism and induce the production of ROS. GLS1 Inhibitor-4 induces apoptosis and shows antitumor activity[1]. | | in vivo | GLS1 Inhibitor-4 (50, 100 mg/kg; i.p.; twice a day for 21 consecutive days) shows antitumor activity in a dose-dependent manne[1]. | Animal Model: | Six-week-old BALB/c SPF nude mice (HCT116 tumor nude mouse xenograft model)[1] | | Dosage: | 50, 100 mg/kg | | Administration: | I.p.; twice a day for 21 consecutive days | | Result: | Inhibited the tumor growth at a dose-dependent manne with the tumor growth inhibition (TGI) values of 35.5% at 50 mg/kg and 47.5% at 100 mg/kg, respectively. |
| | References | [1] Xu X, et al. Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles. Eur J Med Chem. 2022 Jun 5;236:114337. DOI:10.1016/j.ejmech.2022.114337 |
| | GLS1 Inhibitor-4 Preparation Products And Raw materials |
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