Anti-inflammatory agent 47 manufacturers
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| | Anti-inflammatory agent 47 Basic information |
| | Anti-inflammatory agent 47 Chemical Properties |
| Boiling point | 605.920±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.259±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | -1.345±0.10(predicted) |
| | Anti-inflammatory agent 47 Usage And Synthesis |
| Uses | Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research[1]. | | in vivo | Compound Flo8 (15 and 35 mg/kg for i.p., 2 weeks a day) can slow down neuroinflammation and inhibits neuronal apoptosis in the brain of MPTP-induced C57BL/6J mice[1].
| Animal Model: | MPTP C57BL/6J mice model[1] | | Dosage: | 15 mg/kg, 35 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased the mRNA expression of CD86, TNF-α, IL-6 and IL-1β but decreased CD206, Arg-1 and IL-10 in brain tissue.
Inhibited the expression of MPTP-induced phosphorylation of p38, ERK, JNK and NF-κ B.
Reduced dopamine levels in mouse serum in the MPTP group.
Increased the protein expression of Caspase3 and BAX but decreased the expression of Bcl2 after MPTP induction in brain tissue.
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| | References | [1] Shen ZB, et al. Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease. Eur J Med Chem. 2023 Jul 5;255:115417. DOI:10.1016/j.ejmech.2023.115417 |
| | Anti-inflammatory agent 47 Preparation Products And Raw materials |
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