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| | STING Agonist D61 Basic information |
| Product Name: | STING Agonist D61 | | Synonyms: | STING Agonist D61;1H-Benzimidazole-5-carboxamide, 2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1-[3-[[5-[2-(trifluoromethyl)phenyl]-2-oxazolyl]amino]propyl]- | | CAS: | 2850251-27-1 | | MF: | C29H29F3N8O4 | | MW: | 610.59 | | EINECS: | | | Product Categories: | | | Mol File: | 2850251-27-1.mol |  |
| | STING Agonist D61 Chemical Properties |
| density | 1.465±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMSO: Soluble
Methanol: Soluble | | pka | 9.088±0.50(predicted) |
| | STING Agonist D61 Usage And Synthesis |
| Uses | STING agonist-38 (compound 58) is a potent agonist of STING, with the EC50 of 0.05 μM in THP1 cells. STING agonist-38 has certain oral bioactivity[1]. | | References | [1] China Pharmaceutical University. Preparation of benzimidazole compounds for treatment of STING protein function related diseases. China, CN115141182 A 2022-10-04
[2] NAN-NAN CHEN, XIAO-LI XU* Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor[J]. Journal of Medicinal Chemistry, 2023, 66 8: 5584-5610. DOI: 10.1021/acs.jmedchem.2c02046 |
| | STING Agonist D61 Preparation Products And Raw materials |
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