RIPK1-IN-16

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RIPK1-IN-16 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
RIPK1-IN-16 Basic information
Product Name:RIPK1-IN-16
Synonyms:RIPK1-IN-16;1H-1,2,4-Triazole-5-carboxamide, 3-(phenylmethyl)-N-[(3S)-2,3,4,5-tetrahydro-5-methyl-4-thioxo-1,5-benzoxazepin-3-yl]-
CAS:2561431-77-2
MF:C20H19N5O2S
MW:393.46
EINECS:
Product Categories:
Mol File:2561431-77-2.mol
RIPK1-IN-16 Structure
RIPK1-IN-16 Chemical Properties
density 1.424±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka8.740±0.40(predicted)
Safety Information
MSDS Information
RIPK1-IN-16 Usage And Synthesis
UsesRIPK1-IN-16 is an orally active and potent inhibitor of RIPK1. RIPK1-IN-16 inhibits excessive inflammation by blocking RIPK1-mediated necroptosis in vivo. RIPK1-IN-16 protects mouse from TNF-induced systemic inflammatory response syndrome and sepsis[1].
References[1] Ling ZY, et al. Protective Effect of a Novel RIPK1 Inhibitor, Compound 4-155, in Systemic Inflammatory Response Syndrome and Sepsis. Inflammation. 2023 Oct;46(5):1796-1809. DOI:10.1007/s10753-023-01842-1
RIPK1-IN-16 Preparation Products And Raw materials
Tag:RIPK1-IN-16(2561431-77-2) Related Product Information
GSK2982772 RIPK1-IN-16 1H-1,2,4-Triazole-5-carboxamide, N-[(3S)-7-(2-cyclopropylethynyl)-2,3,4,5-tetrahydro-5-methyl-4-oxo-1,5-benzoxazepin-3-yl]-3-(phenylmethyl)- 5-Pyrimidinecarboxamide, 2-[(3S)-3-amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]- NA GSK-2593074A)