|
|
| | Catalpalactone Basic information |
| Product Name: | Catalpalactone | | Synonyms: | Catalpalactone;1(3H)-Isobenzofuranone,3-(5,6-dihydro-6,6-dimethyl-2-oxo-2H-pyran-3-yl)- | | CAS: | 1585-68-8 | | MF: | C15H14O4 | | MW: | 258.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1585-68-8.mol |  |
| | Catalpalactone Chemical Properties |
| Melting point | 110-111 °C | | Boiling point | 467.1±45.0 °C(Predicted) | | density | 1.269±0.06 g/cm3(Predicted) | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Powder | | LogP | 2.050 (est) |
| | Catalpalactone Usage And Synthesis |
| Uses | Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities[1][2]. | | Definition | ChEBI: Catalpalactone is a member of 2-benzofurans. | | target | cAMP | NO | | References | [1] Kim HY, et al. Anti-Inflammatory Effects of Catalpalactone Isolated from Catalpa ovata in LPS-Induced RAW264.7 Cells. Molecules. 2019 Mar 29;24(7):1236. DOI:10.3390/molecules24071236
[2] Huang HS, et al. Effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Environ Toxicol Pharmacol. 2008 Jul;26(1):86-91. DOI:10.1016/j.etap.2008.02.005 |
| | Catalpalactone Preparation Products And Raw materials |
|