- 1-Isopropylpyrazole
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2026-09-01
- CAS:18952-87-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
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| | 1-Isopropylpyrazole Basic information |
| Product Name: | 1-Isopropylpyrazole | | Synonyms: | 1-isopropylpyrazole;1-(1-Methylethyl)-1H-pyrazole;2-isopropyl-1H-Pyrazole;1-propan-2-ylpyrazole;1-(propan-2-yl)-1H-pyrazole;1H-Pyrazole, 1-(1-methylethyl)-;1-Isopropyl-1H-pyrazole | | CAS: | 18952-87-9 | | MF: | C6H10N2 | | MW: | 110.16 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 18952-87-9.mol |  |
| | 1-Isopropylpyrazole Chemical Properties |
| Boiling point | 143 °C | | density | 0.96 | | refractive index | 1.4620 to 1.4660 | | Fp | 43 °C | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | pka | 2.29±0.10(Predicted) | | color | Colorless to Almost colorless |
| RIDADR | UN 1993 3/PG III | | HazardClass | 3 | | PackingGroup | III | | HS Code | 2933199090 |
| | 1-Isopropylpyrazole Usage And Synthesis |
| Synthesis | The reaction mixture was stirred at 120 °C for 90 h with pyrazole (5 g, 73.44 mmol) and 2-bromopropane (15 mL, 2 eq.), NaHCO3 (12.2 g, 2 eq.) was added as base. During the reaction, 2-bromopropane was supplemented as needed to maintain the reaction volume. Upon completion of the reaction, the insoluble solids were removed by filtration and the filtrate was purified by distillation. The colorless syrupy product 1-isopropyl-1H-pyrazole (4.6 g, 57% yield) with a boiling point of 148°C was collected. | | References | [1] Patent: WO2006/108591, 2006, A1. Location in patent: Page/Page column 112
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1923 - 1936
[3] Patent: WO2005/12254, 2005, A1. Location in patent: Page/Page column 129
[4] Patent: US2009/170873, 2009, A1. Location in patent: Page/Page column 48 |
| | 1-Isopropylpyrazole Preparation Products And Raw materials |
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