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| | C18 Ganglioside GM2-d7 (d18:1/18:0-d7) (ammonium salt, synthetic) Basic information |
| | C18 Ganglioside GM2-d7 (d18:1/18:0-d7) (ammonium salt, synthetic) Chemical Properties |
| solubility | Methanol: Soluble |
| | C18 Ganglioside GM2-d7 (d18:1/18:0-d7) (ammonium salt, synthetic) Usage And Synthesis |
| Description | C18 Ganglioside GM2-d7 (d18:1/18:0-d7) is intended for use as an internal standard for the quantification of C18 ganglioside GM2 by GC- or LC-MS. C18 Ganglioside GM2 is a monosialylated ganglioside found in the mammalian brain where it is localized to the cell membrane.1 It accumulates in Tay-Sachs and Sandhoff disease, which are neurodegenerative disorders characterized by deficiency of lysosomal β-hexosaminidase A and B, respectively.2 Ganglioside GM2 disrupts the function of immune cells and, when used at a concentration of 25 µM, increases migration and invasion of SK-RC-45 cells with no effect on proliferation.3 This product is fully synthetic and has no variations in the fatty acyl chain or sphingoid backbone. It is intended for use as an analytical standard for the quantification of C18 ganglioside GM2 by GC-MS.WARNING This product is not for human or veterinary use. | | References | [1] SCHNAAR R L. Gangliosides of the Vertebrate Nervous System[J]. Journal of Molecular Biology, 2016, 428 16: Pages 3325-3336. DOI: 10.1016/j.jmb.2016.05.020
[2] RENA C. BAEK. Comparative Analysis of Brain Lipids in Mice, Cats, and Humans with Sandhoff Disease[J]. Lipids, 2008, 44 3: 197-205. DOI: 10.1007/s11745-008-3268-0
[3] MANJARI KUNDU . Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway[J]. Biochimica et biophysica acta. Molecular cell research, 2016, 1863 7: Pages 1472-1489. DOI: 10.1016/j.bbamcr.2016.04.004 |
| | C18 Ganglioside GM2-d7 (d18:1/18:0-d7) (ammonium salt, synthetic) Preparation Products And Raw materials |
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