1-tert-butyl-1H-pyrazole-4-carboxylic acid manufacturers
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| | 1-tert-butyl-1H-pyrazole-4-carboxylic acid Basic information |
| Product Name: | 1-tert-butyl-1H-pyrazole-4-carboxylic acid | | Synonyms: | 1-tert-butyl-1H-pyrazole-4-carboxylic acid;1-tert-butylpyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-(1,1-dimethylethyl)-;1-(1,1-Dimethylethyl)-1H-pyrazole-4-carboxylic acid;1-(tert-Butyl)-1H-pyrazol-4-carboxylic acid | | CAS: | 950858-65-8 | | MF: | C8H12N2O2 | | MW: | 168.19 | | EINECS: | | | Product Categories: | | | Mol File: | 950858-65-8.mol |  |
| | 1-tert-butyl-1H-pyrazole-4-carboxylic acid Chemical Properties |
| Boiling point | 306.2±15.0 °C(Predicted) | | density | 1.15±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.91±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 1-tert-butyl-1H-pyrazole-4-carboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1-tert-butyl-1H-pyrazole-4-carboxylic acid from ethyl 1-tert-butyl-1H-pyrazole-3-carboxylate:
1. In 8 mL of THF-MeOH-H2O (3:1:1, v/v) mixed solvent, ethyl 1-tert-butyl-1H-pyrazole-3-carboxylate (327 mg, 1.66 mmol) and LiOH (120 mg, 5.0 mmol) were added.
2. The reaction mixture was stirred at 25 °C for 12 hours.
3. After completion of the reaction, H2O and EtOAc were added to the mixture and acidified with 10% HCl solution.
4. The organic layer was separated, dried with Na2SO4 and concentrated under reduced pressure to afford the target product 1-tert-butyl-1H-pyrazole-4-carboxylic acid (217 mg, 78% yield).
Mass spectral data: m/z 168. | | References | [1] Patent: WO2007/71963, 2007, A2. Location in patent: Page/Page column 59 |
| | 1-tert-butyl-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials |
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