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| | COX-2 Rabbit Monoclonal Antibody (Clone RM348) Basic information |
| | COX-2 Rabbit Monoclonal Antibody (Clone RM348) Chemical Properties |
| | COX-2 Rabbit Monoclonal Antibody (Clone RM348) Usage And Synthesis |
| Description | Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins.1,2 The COX component converts arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2; Item No. 17010), and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020). COX2 expression is induced by a variety of stimuli, including phorbol esters, LPS, and cytokines and is responsible for the biosynthesis of PGs under acute inflammatory conditions.3,4 Thus, COX-2 has been the focus of attention for non-steroidal anti-inflammatory drug (NSAID) development. Cayman’s COX-2 Rabbit Monoclonal Antibody (Clone RM348) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | COX-2 Rabbit Monoclonal Antibody (Clone RM348) Preparation Products And Raw materials |
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