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| | ASPOCHALASIN D Basic information |
| Product Name: | ASPOCHALASIN D | | Synonyms: | ASPOCHALASIN D;1H-Cycloundec(d)isoindole-1,15(2H)-dione, 3,3a,4,6a,9,10,11,12-octahyd ro-11,12-dihydroxy-4,5,8-trimethyl-3-(2-methylpropyl)-, (3S,3aR,4S,6aS ,7E,11R,12S,13E,15aS)-;[3S,13E,17S,18S,19E,(-)]-17,18-Dihydroxy-14-methyl-3-(2-methylpropyl)-10-nor[11]cytochalasa-6,13,19-triene-1,21-dione;isoaspochalasinC | | CAS: | 71968-02-0 | | MF: | C24H35NO4 | | MW: | 401.54 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 71968-02-0.mol |  |
| | ASPOCHALASIN D Chemical Properties |
| Boiling point | 607.6±55.0 °C(Predicted) | | density | 1.15±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 13.10±0.70(Predicted) |
| | ASPOCHALASIN D Usage And Synthesis |
| Description | Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that was initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml. Aspochalasin D is more cytotoxic, via apoptosis, to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium (IC50s = 0.49 and 1.9 μg/ml, respectively). | | Uses | Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that is initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml.2 Aspochalasin D is more cytotoxic, via apoptosis, to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium (IC50s=0.49 and 1.9 μg/mL, respectively). | | References | [1] Gebhardt, et al. Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic fungus Aspergillus niveus LU 9575 I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 57(11), 707-714 (2004). |
| | ASPOCHALASIN D Preparation Products And Raw materials |
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