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Heterochem |
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027-88041443 13072715837 |
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sales@hetero-chem.com |
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| | 4-(Pyrimidin-2-yl)benzoic acid Basic information |
| Product Name: | 4-(Pyrimidin-2-yl)benzoic acid | | Synonyms: | AKOS BAR-2339;4-(PYRIMIDIN-2-YL)BENZOIC ACID;Benzoic acid, 4-(2-pyrimidinyl)- (9CI);4-Pyrimidin-2-yl-benzoicacid95%;4-(2-pyrimidinyl)benzoate;Benzoic acid, 4-(2-pyrimidinyl)-;4-(Pyrimidin-2-yl)benzoic acid MFCD01318668;4-(2-Pyrimidinyl)benzoic acid | | CAS: | 199678-12-1 | | MF: | C11H8N2O2 | | MW: | 200.19 | | EINECS: | | | Product Categories: | pharmacetical;QUINAZOLINE | | Mol File: | 199678-12-1.mol |  |
| | 4-(Pyrimidin-2-yl)benzoic acid Chemical Properties |
| Melting point | 238 °C | | Boiling point | 301.5±34.0 °C(Predicted) | | density | 1.302±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.67±0.10(Predicted) | | Appearance | Off-white to light brown Solid |
| Hazard Codes | Xn | | Risk Statements | 22 | | Hazard Note | Harmful | | HS Code | 2933599590 |
| | 4-(Pyrimidin-2-yl)benzoic acid Usage And Synthesis |
| Uses | 4-Pyrimidin-2-yl-benzoic acid (cas# 199678-12-1) is a useful reactant for the synthesis of alkylimino-quinolinyl isoindolones. | | Synthesis | In a 250 mL round bottom flask, the compound obtained in the previous step (4.4 g, 20.54 mmol, 1.00 eq.), sodium hydroxide (2.4 g, 60.00 mmol, 2.92 eq.), and methanol (50 mL) were mixed. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7 with 1 M hydrochloric acid. the precipitated solid was collected by filtration to give 3.15 g of light yellow solid product in 77% yield. | | References | [1] Patent: US2016/237043, 2016, A1. Location in patent: Paragraph 0553; 0555 |
| | 4-(Pyrimidin-2-yl)benzoic acid Preparation Products And Raw materials |
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