3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-]

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3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] Basic information
Product Name:3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-]
Synonyms:3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-];Destruxin B2;Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-valyl-N-methyl-L-valyl]
CAS:79386-00-8
MF:C29H49N5O7
MW:579.74
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Mol File:79386-00-8.mol
3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] Structure
3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] Chemical Properties
Boiling point 870.7±65.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Dichloromethane: 10 mg/ml; DMSO: 10 mg/ml
pka13.44±0.70(Predicted)
Safety Information
MSDS Information
3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] Usage And Synthesis
DescriptionDestruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities. It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM). Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM. It is also phytotoxic to B. napus leaves.
UsesDestruxin B2 (compound 5) is a natural depsipeptide that can be inhibits hepatitis B surface antigen (HBsAg) secretion in Hep3B cells with an IC50 1.30 μM[1].
References[1] Yeh SF, et al. Study of structure-activity correlation in destruxins, a class of cyclodepsipeptides possessing suppressive effect on the generation of hepatitis B virus surface antigen in human hepatoma cells. Biochem Biophys Res Commun. 1996 Dec 4;229(1):65-72. DOI:10.1006/bbrc.1996.1758
3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-] Preparation Products And Raw materials
Tag:3-Isopropylcyclo[D-Lac-L-Pro-L-Val-N-methyl-L-Val-N-methyl-L-Ala-βAla-](79386-00-8) Related Product Information
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