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| | 5-Ethyl-2,4-piperidinedione Basic information |
| Product Name: | 5-Ethyl-2,4-piperidinedione | | Synonyms: | 5-Ethylpiperidine-2,4-dione;2,4-Piperidinedione, 5-ethyl-;5-Ethyl-2, 4-piperidinedione - [E14290];5-ethylhexahydropyridine-2,4-dione;5-Ethyl-2,4-piperidinedione | | CAS: | 73290-32-1 | | MF: | C7H11NO2 | | MW: | 141.17 | | EINECS: | | | Product Categories: | | | Mol File: | 73290-32-1.mol |  |
| | 5-Ethyl-2,4-piperidinedione Chemical Properties |
| Melting point | 72-74 °C | | Boiling point | 156-157 °C(Press: 1 Torr) | | density | 1.060±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 12.04±0.70(Predicted) |
| | 5-Ethyl-2,4-piperidinedione Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 5-ethyl-2,4-piperidinedione from 1-Boc-5-ethyl-2,4-dioxopiperidine was as follows: 1-Boc-5-ethyl-2,4-dioxopiperidine was dissolved in trifluoroacetic acid (TFA, 10 mL), and the reaction was stirred for 2 h at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator and the resulting residue was purified by column chromatography (eluent: hexane/ethyl acetate, 1:2, v/v) to afford 5-ethylpiperidine-2,4-dione in 52% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-D6): δ 0.89 (t, J = 7.56 Hz, 3H), 1.35 (m, 1H), 1.69 (m, 1H), 2.39 (m, 1H), 3.14-3.38 (m, 4H), 8.05 (s, 1H); ESI (+) MS: m/z 142 (MH+) . | | References | [1] Patent: US2007/142414, 2007, A1. Location in patent: Page/Page column 18
[2] Synthesis, 2007, # 20, p. 3185 - 3190 |
| | 5-Ethyl-2,4-piperidinedione Preparation Products And Raw materials |
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