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| | 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one Basic information |
| Product Name: | 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one | | Synonyms: | 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one;1,2-dihydropyrazolo[3,4-b]pyridin-3-one;1,2-Dihydro-3H-pyrazolo[3,4-b]pyridin-3-one;3-Hydroxy-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridin-3(2H);1H,2H-pyrazolo[3,4-b]pyridin-3-one;3H-Pyrazolo[3,4-b]pyridin-3-one, 1,2-dihydro-;1H,2H,3H-pyrazolo[3,4-b]pyridin-3-one | | CAS: | 2942-43-0 | | MF: | C6H5N3O | | MW: | 135.12 | | EINECS: | | | Product Categories: | | | Mol File: | 2942-43-0.mol | ![1H-Pyrazolo[3,4-b]pyridin-3(2H)-one Structure](CAS/GIF/2942-43-0.gif) |
| | 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one Chemical Properties |
| Melting point | 234-236° | | density | 1.62±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 8.93±0.20(Predicted) | | Appearance | Yellow to brown Solid |
| | 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-one from ethyl 2-chloropyridine-3-carboxylate: a mixed solution of 5 g (26.94 mmol) of ethyl 2-chloropyridine-3-carboxylate and 4.76 g (80.82 mmol) of 85% hydrazine hydrate in 10 ml of ethanol was heated and refluxed for 6 hours. After completion of the reaction, the reaction mixture was concentrated. The product 3.5 g was obtained in 96% yield and the [M+H]+ peak was detected as 135.9 by mass spectrometry. | | References | [1] Patent: WO2005/73199, 2005, A1. Location in patent: Page/Page column 31
[2] Patent: US2005/197348, 2005, A1. Location in patent: Page/Page column 10 |
| | 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one Preparation Products And Raw materials |
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