| Company Name: |
Shanghai URChem Limited Gold |
| Tel: |
+86-021-50890968，021-50891159 +86-18601776121 |
| Email: |
danny@urchem.com |
| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
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saleschina@alfa-asia.com |
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| | Ethyl 2-chloronicotinate Basic information |
| | Ethyl 2-chloronicotinate Chemical Properties |
| Melting point | 68 C | | Boiling point | 78°C (0.1 mmHg) | | density | 1.2445 g/cm3(Temp: 25 °C) | | refractive index | 1.5210-1.5250 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | -1.32±0.10(Predicted) | | form | Liquid | | color | Colorless to Light yellow to Light orange | | Major Application | pharmaceutical | | InChI | InChI=1S/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3 | | InChIKey | PMIMPBYTPPRBGD-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC=C1C(OCC)=O | | CAS DataBase Reference | 1452-94-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-60-37 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2 |
| Provider | Language |
|
ALFA
| English |
| | Ethyl 2-chloronicotinate Usage And Synthesis |
| Chemical Properties | Light yellow liquid | | Uses | Ethyl 2-chloronicotinate,is used as a pharmaceutical intermediate. | | Synthesis Reference(s) | Tetrahedron, 51, p. 13177, 1995 DOI: 10.1016/0040-4020(95)00788-A | | Synthesis | 2-Chloropyridine-3-carboxylic acid (7.9 g) and thionyl chloride (45 ml) were heated for 3 hours in benzene (65 ml) under reflux. The reaction mixture was concentrated to leave an oil, which was added dropwise to ethanol (40 ml). The mixture was heated for a further one hour under reflux. The solvent was distilled, and the residue was dissolved in toluene. The solution was dried over anhydrous magnesium sulfate. The solvent was distilled to leave Ethyl 2-chloronicotinate (8.4 g, 90%) as a pale yellow oil. |
| | Ethyl 2-chloronicotinate Preparation Products And Raw materials |
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