MIVOTILATE
| 中文名称 | MIVOTILATE |
|---|---|
| 中文同义词 | 化合物 T16082;化合物 MIVOTILATE |
| 英文名称 | Unii-0789652qul |
| 英文同义词 | Ccris 8109;Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate;Mivotilate [inn];Unii-0789652qul;2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester;Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate;Propanoic acid, 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-, 1-methylethyl ester;YH439 >=98% (HPLC) |
| CAS号 | 130112-42-4 |
| 分子式 | C12H14N2O3S3 |
| 分子量 | 330.45 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 130112-42-4.mol |
| 结构式 |  |
MIVOTILATE 性质
| 密度 | 1.467±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.89±0.70(Predicted) |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C12H14N2O3S3/c1-6(2)17-10(16)8(11-19-5-20-11)9(15)14-12-13-7(3)4-18-12/h4,6H,5H2,1-3H3,(H,13,14,15) |
| InChIKey | WOUUWUGULFOVHG-UHFFFAOYSA-N |
| SMILES | CC(C)OC(=O)C(\C(=O)Nc1nc(C)cs1)=C2\SCS2 |
Mivotilate 是一种非毒性的，有效的芳烃受体 (aryl hydrocarbon receptor) 激动剂，具有护肝作用。
Aryl hydrocarbon receptor
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor. Mivotilate (YH439) has a novel activation mode that tolerates mutation of histidine 285 to tyrosine. Mivotilate induces cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor.
Mivotilate (YH439, 150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats, but shows no obvious effect on NADPH-dependent P450 oxidoreductase activity. Mivotilate (75-300 mg/kg) rapidly decreases immunoreactive CYP2E1 protein. Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100242R | MIVOTILATE Mivotilate (Standard) | 130112-42-4 | 1 mg | 1196元 |
| 2026/06/05 | HY-100242R | MIVOTILATE Mivotilate (Standard) | 130112-42-4 | 5 mg | 2990元 |