- COMU
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2026-08-14
- CAS:1075198-30-9
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 30tons/month
- COMU
-
-
2025-04-04
- CAS:1075198-30-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1ton
- COMU
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- $15.00
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2021-07-13
- CAS:1075198-30-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
Related articles - An efficient Coupling Reagent: COMU
- COMU is a more efficient alternative to classical benzotriazole immonium salts regarding racemization suppression, coupling ef....
- Dec 4，2023
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| Product Name: | COMU | | Synonyms: | 4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate;1-[1-(Cyano-2-ethoxy-2-oxoethylideneaMinooxy)-diMethylaMino-Morpholino]-uroniuM hexafluorophosphate;4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium(COMU?);{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxy}dimethylamino(morpholin-4-yl)carbenium hexafluorophosp;(1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium Hexafluorophosphate (This product is only available in Japan.);COMU(R) 97%;elagolix intermediate 13;COMU
4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)-amino]-oxayl}-(dimethylamino)-methylene}-hexafluorophosphate morpholinium | | CAS: | 1075198-30-9 | | MF: | C12H19F6N4O4P | | MW: | 428.27 | | EINECS: | 682-899-5 | | Product Categories: | | | Mol File: | 1075198-30-9.mol |  |
| Melting point | ca 160℃ | | Boiling point | 127-129 °C | | storage temp. | Store at -15°C to -25°C. | | solubility | Soluble in DMF 1mmol in 2mL. | | form | Powder or Solid | | color | White to pale yellow | | Sensitive | Air & Moisture Sensitive | | Major Application | peptide synthesis | | InChI | InChI=1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-; | | InChIKey | GPDHNZNLPKYHCN-DZOOLQPHSA-N | | SMILES | C1N(/C(/O/N=C(\C(OCC)=O)/C#N)=[N+](\C)/C)CCOC1.[P-](F)(F)(F)(F)(F)F |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | HS Code | 2934 99 90 | | Storage Class | 11 - Combustible Solids |
| Description | COMU is a third-generation uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxylamine)acetate (Oxyma) and a morpholino carbon skeleton. The presence of the morpholino group has a marked influence on the reagent's solubility, stability, and reactivity. COMU performed exceptionally well in the presence of only 1 equiv of base, confirming the effect of the hydrogen bond acceptor in the reaction. The by-products of COMU are water soluble and easily removed, making it an excellent choice of coupling reagent for solution-phase peptide synthesis[1]. | | Uses | (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholinocarbenium hexafluorophosphate is used as a coupling reagent in the peptide synthesis. It is suitable for solution phase & solid phase peptide synthesis, visual or colorimetric reaction monitoring possible. | | Uses | COMU – Safer and More Efficient Peptide Coupling Reagent
Advantages
- Equal or even superior performance to HATU
- Non-explosive (does not contain benzotriazole moiety)
- Suitable for solution phase & solid phase peptide synthesis
- Utmost retention of configuration – low to non-existent racemization
- High solubility and stability in typical solvents
- Visual or colorimetric reaction monitoring possible
- Easy removal of water-soluble by-products
| | General Description | This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". | | reaction suitability | reaction type: Coupling Reactions | | References | [1] Ayman El-Faham, Fernando Albericio. “COMU: A third generation of uronium-type coupling reagents.” Journal of Peptide Science 16 1 (2009): 6–9.
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| | COMU Preparation Products And Raw materials |
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