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| | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Basic information |
| Product Name: | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride | | Synonyms: | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride;SB 612111 hydrochloride;SB 612111;(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]Methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol Hydrochloride;(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]Methyl]-6,7,8,9-tetrahydro-1-Methyl-5H-benzocyclohepten-5-ol Hydrochloride;(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol;(5S,7S)-7-((4-(2,6-DICHLOROPHENYL)PIPERIDIN-1-YL)METHYL)-1-METHYL-6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL HCL;5H-Benzocyclohepten-5-ol, 7-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-, (5S,7S)- | | CAS: | 371980-98-2 | | MF: | C24H29Cl2NO | | MW: | 418.4 | | EINECS: | | | Product Categories: | Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 371980-98-2.mol | ![7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Structure](CAS/GIF/371980-98-2.gif) |
| | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Chemical Properties |
| Boiling point | 530.9±50.0 °C(Predicted) | | density | 1.207 | | storage temp. | Store at -20°C | | solubility | DMSO: soluble15mg/mL, clear | | form | powder | | pka | 14.68±0.40(Predicted) | | color | white to beige | | InChI | 1S/C24H29Cl2NO.ClH/c1-16-4-2-5-20-19(16)9-8-17(14-23(20)28)15-27-12-10-18(11-13-27)24-21(25)6-3-7-22(24)26;/h2-7,17-18,23,28H,8-15H2,1H3;1H/t17-,23-;/m0./s1 | | InChIKey | DCKUVQADDNMWEF-DQFHVVJASA-N | | SMILES | Clc1c(c(ccc1)Cl)C2CCN(CC2)C[C@@H]3C[C@@H](c4c(c(ccc4)C)CC3)O.Cl |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Usage And Synthesis |
| Uses | A selective nociceptin/orphanin FQ receptor antagonist, 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride can act as a potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response. | | Uses | A selective nociceptin/orphanin FQ receptor antagonist. A potentially useful adjunct to chronic pain therapy with opioids and can be used to treat conditions in which thermal hyperalgesia is a significant component of the pain response. | | Biochem/physiol Actions | SB-612111 is a potent antagonist of the nociceptin receptor ORL-1. SB-612111 binds to ORL-1 with high affinity (Ki = 0.33 nM) but has very low affinity for classic opioid receptors. The compound SB-612111 antagonizes the anti-morphine effects of nociceptin and blocks nociceptin-induced thermal hyperalgesia. |
| | 7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-olhydrochloride Preparation Products And Raw materials |
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