9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene

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9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene Suppliers list
Company Name: EnliPharma Technology Co., Ltd  
Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene Basic information
Product Name:9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene
Synonyms:9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene;Pyrazolo[4,3-b]pyrido[4,3-e][1,4]diazepine, 5-(2-chlorophenyl)-8-ethyl-1,2-dihydro-3-methyl-;TY-011;5-(2-chlorophenyl)-8-ethyl-3-methyl-2,10-dihydropyrazolo[3,4-b]pyrido[4,3-e][1,4]diazepine
CAS:1389439-77-3
MF:C18H16ClN5
MW:337.81
EINECS:
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Mol File:1389439-77-3.mol
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene Structure
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene Chemical Properties
Boiling point 541.8±50.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at 0-8 °C
pka16.46±0.40(Predicted)
Safety Information
MSDS Information
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene Usage And Synthesis
UsesTY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research[1].
IC 50Aurora A; Aurora B
References[1] Jiang T, et al. Antitumor activity of a novel Aurora A/B kinases inhibitor TY-011 against gastric cancer by inducing DNA damage. Anticancer Drugs. 2020 Jun;31(5):440-451. DOI:10.1097/CAD.0000000000000928
9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene Preparation Products And Raw materials
Tag:9-(2-Chloro-phenyl)-6-ethyl-1-Methyl-2,4-dihydro-2,3,4,7,10-pentaaza-benzo[f]azulene(1389439-77-3) Related Product Information
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