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Insulin degludec

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Company Name: ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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Products Intro: Product Name:Insulin Degludec
CAS:844439-96-9
Purity:99% Package:25KG;3USD|10KG;6USD|1KG;9USD
Company Name: ANHUI WITOP BIOTECH CO., LTD
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Products Intro: Product Name:Insulin degludec
CAS:844439-96-9
Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:Insulin degludec USP/EP/BP
CAS:844439-96-9
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Yantai Fenglu Fine Chemical Co. LTD
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Products Intro: Product Name:degludec insulin
CAS:844439-96-9
Purity:99.0% Package:1g/Bag;USD
Company Name: Aladdin Scientific
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Products Intro: Product Name:Insulin degludec
CAS:844439-96-9
Purity:99% Package:$220.9/5mg;$350.9/10mg;$700.9/25mg;$1100.9/50mg;Bulk package Remarks:99%

Insulin degludec manufacturers

  • Insulin degludec
  • Insulin degludec pictures
  • $30.00
  • 2024-03-31
  • CAS:844439-96-9
  • Min. Order: 10BOX
  • Purity: 99
  • Supply Ability: 20TONS
Insulin degludec Basic information
Product Name:Insulin degludec
Synonyms:Insulin degludec;Insulin degludec USP/EP/BP;degludec insulin;Insulin Degludec/ Degludec Insulin;Research Grade Insulin Degludec
CAS:844439-96-9
MF:C274H411N65O81S6
MW:6103.97204
EINECS:
Product Categories:API
Mol File:844439-96-9.mol
Insulin degludec Structure
Insulin degludec Chemical Properties
storage temp. Store at -20°C
form Solid
color White to off-white
InChIKeyFYZPCMFQCNBYCY-WIWKJPBBSA-N
Safety Information
MSDS Information
Insulin degludec Usage And Synthesis
UsesInsulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes[1][2].
in vivo

Insulin degludec (5 U/kg; s.c. once daily for 30 days) affects glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia[1].

Animal Model:Male Swiss mice with diabetes[1]
Dosage:5 U/kg
Administration:Subcutaneous injection; 5 U/kg once daily for 30 days
Result:Showed a fast response to insulin-induced hypoglycemia with a glycemic level at or slightly under 100 mg/dl after 60 min and this response effect can be abolished by cortisol. Diminished rates of glucose production and showed a low lactate production in livers. Increased the number of hepatocytes.
References[1] Bataglini C, et al. Insulin degludec and glutamine dipeptide modify glucose homeostasis and liver metabolism in diabetic mice undergoing insulin-induced hypoglycemia. J Appl Biomed. 2021 Dec;19(4):210-219. DOI:10.32725/jab.2021.025
[2] Hartmann T, et al. Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function. Cardiovasc Diabetol. 2016 Jul DOI:10.1186/s12933-016-0410-9
Insulin degludec Preparation Products And Raw materials
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