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| | MK-2206 Basic information |
| Product Name: | MK-2206 | | Synonyms: | MK-2206(FREE BASE);8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-ol;1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-;Benodanil Impurity 8 | | CAS: | 1032349-93-1 | | MF: | C25H21N5O | | MW: | 407.47 | | EINECS: | | | Product Categories: | API | | Mol File: | 1032349-93-1.mol |  |
| | MK-2206 Chemical Properties |
| | MK-2206 Usage And Synthesis |
| Uses | A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM. | | Definition | ChEBI: MK-2206 is an organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted at positions 8 and 9 respectively by 4-(1-aminocyclobutyl)phenyl and phenyl groups. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is functionally related to a 1,6-naphthyridine. | | IC 50 | Akt1: 8 nM (IC50); Akt2: 12 nM (IC50); Akt3: 65 nM (IC50) |
| | MK-2206 Preparation Products And Raw materials |
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