TH1338 manufacturers
- TH1338
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- $935.00
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2026-08-27
- CAS:1258494-60-8
- Purity: 98.77%
- Supply Ability: 10g
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| Product Name: | TH1338 | | Synonyms: | TH1338;TH 1338; TH-1338;1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 5-amino-4,11-diethyl-4-hydroxy-, (4S)-;7-ethyl-14-amino-camptothecin;TH-1318;(19S)-21-amino-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.0?,?.01?,2?]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;(S)-5-Amino-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione | | CAS: | 1258494-60-8 | | MF: | C22H21N3O4 | | MW: | 391.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1258494-60-8.mol |  |
| | TH1338 Chemical Properties |
| Boiling point | 721.7±60.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | pka | 11.08±0.40(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | TH1338 Usage And Synthesis |
| Uses | TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile[1][2]. | | References | [1] Jian-Xin Duan, et al. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment. J Med Chem. 2011 Mar 24;54(6):1715-23. DOI:10.1021/jm101354u
[2] Xia Cheng, et al. Preparation, Characterization, and In Vivo Study of 7-Ethyl-14-Aminocamptothecin-Loaded Poly(Ethylene Glycol)2000 -Poly(Lactic Acid)2000 Polymeric Micelles Against H460 Human Nonsmall Cell Lung Carcinoma. J Pharm Sci. 2015 Nov;104(11):3934-3942. DOI:10.1002/jps.24613 |
| | TH1338 Preparation Products And Raw materials |
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