tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate manufacturers
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| | tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Basic information |
| | tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Chemical Properties |
| Boiling point | 322.1±31.0 °C(Predicted) | | density | 1.02±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 12.40±0.40(Predicted) | | Appearance | White to off-white Solid | | Optical Rotation | -32.6°(C=0.01g/mL, MEOH, 20°C, 589nm) |
| | tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of tert-butyl ((1S,3R)-3-aminocyclohexyl)carbamate from benzyl ((1R,3S)-cyclohexane-1,3-diyl)dicarbamate (dextro) was as follows: to tert-butyl ((1S,3R)-3-(benzyloxycarbonylamino)cyclohexylcarbamate (10 g, 28.4 mmol) in EtOH (473 mL) A 10% w/w Pd/C (450 mg) was added to the degassed solution. The reaction mixture was stirred under H2 (1 atm) atmosphere for 5 hours. Upon completion of the reaction, the mixture was filtered through a Celite pad (and washed with EtOH) and the filtrate was concentrated under reduced pressure to afford tert-butyl ((1S,3R)-3-aminocyclohexyl)carbamate (6.08 g, 28.4 mmol, 100% yield) as a white solid. | | References | [1] Patent: WO2015/58140, 2015, A1. Location in patent: Paragraph 00310
[2] Patent: WO2015/154039, 2015, A2. Location in patent: Paragraph 248; 249; 446; 447
[3] Patent: WO2016/58544, 2016, A1. Location in patent: Paragraph 165; 166; 375 |
| | tert-butyl (1S,3R)-3-aMinocyclohexylcarbaMate Preparation Products And Raw materials |
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