| Company Name: |
SPIRO PHARMA |
| Tel: |
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| Email: |
eric_feng1954@126.com |
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| | ZD 9331 Basic information |
| Product Name: | ZD 9331 | | Synonyms: | Plevitrexed ((R)-isoMer);IEJSCSAMMLUINT-OAQYLSRUSA-N;(R)-BGC9331;(R)-Plevitrexed;(R)-ZD 9331;1H-Tetrazole-5-butanoic acid, α-[[4-[[(1,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-, (αR)- (9CI) | | CAS: | 153537-74-7 | | MF: | C26H25FN8O4 | | MW: | 532.53 | | EINECS: | | | Product Categories: | | | Mol File: | 153537-74-7.mol |  |
| | ZD 9331 Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | pka | 3.35±0.10(Predicted) |
| | ZD 9331 Usage And Synthesis |
| Uses | (R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor[2]. (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Marsham PR, et al. Designandsynthesisofpotentnon-polyglutamatablequinazolineantifolatethymidylatesynthaseinhibitors. J Med Chem.1999 Sep 23;42(19):3809-20. DOI:10.1021/jm9803727
[2] Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem.2013Jul 11;56(13):5446-55. DOI:10.1021/jm400490e |
| | ZD 9331 Preparation Products And Raw materials |
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