4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine
概述 用途与合成方法 MSDS 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine价格(试剂级) 上下游产品信息
| 中文名称 | 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine |
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| 中文同义词 | MI 0202;化合物 T28036;化合物MI-2-2;4-(4-(5,5-二甲基-4,5-二氢噻唑-2-基)哌嗪-1-基)-6-(2,2,2-三氟乙基)噻吩并[2,3-D]嘧啶 |
| 英文名称 | 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine |
| 英文同义词 | 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine;4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidin;4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-;Thieno[2,3-d]pyrimidine, 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)-;cell proliferation,inhibit,menin-MLL interaction,Epigenetic Reader Domain,Inhibitor,Hoxa9 expression,differentiation,leukemia;1-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-4-[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]piperazine |
| CAS号 | 1454920-20-7 |
| 分子式 | C17H20F3N5S2 |
| 分子量 | 415.5 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 1454920-20-7.mol |
| 结构式 | ![4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine 结构式](CAS/20150408/GIF/1454920-20-7.gif) |
4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine 性质
| 溶解度 | DMSO: Soluble: =10 mg/ml Ethanol: Slightly Soluble: 0.1-1 mg/ml |
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| 形态 | 固体 |
| 颜色 | 白色至米白色 |
4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine 用途与合成方法
MI-2-2 是一种有效的 menin-MLL 抑制剂。MI-2-2 以低纳摩尔亲和力 (Kd=22 nM) 与 menin 结合，并非常有效地破坏 menin 和 MLL 之间的二价蛋白质-蛋白质相互作用。MI-2-2 在 MLL 白血病细胞中具有特异且非常显著的活性，包括抑制细胞增殖、下调 Hoxa9 表达和分化。
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108350 | 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine MI-2-2 | 1454920-20-7 | 1 mg | 600元 |
| 2026/06/05 | HY-108350 | 4-(4-(5,5-diMethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyriMidine MI-2-2 | 1454920-20-7 | 5 mg | 1500元 |