|
|
| | EzetiMibe-d4 Basic information |
| Product Name: | EzetiMibe-d4 | | Synonyms: | (3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one;[2H4]-Ezetimibe;Ezetimibe Impurity 119;Ezetimibe D4Q: What is
Ezetimibe D4 Q: What is the CAS Number of
Ezetimibe D4 Q: What is the storage condition of
Ezetimibe D4;Ezetimibe-d4-1;(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl-2,3,5,6-d4)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one;(3R,4S)-3-[(3S)-3-[4-fluoro(2,3,5,6-2H?)phenyl]-3-hydroxypropyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one;D4-Ezetimibe | | CAS: | 1093659-89-2 | | MF: | C24H21F2NO3 | | MW: | 409.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1093659-89-2.mol |  |
| | EzetiMibe-d4 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | form | A solid | | color | White to off-white |
| | EzetiMibe-d4 Usage And Synthesis |
| Description | Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1. Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids. | | Uses | Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor. | | References | [1] WANG D Q H. Regulation of intestinal cholesterol absorption.[J]. Annual review of physiology, 2007, 69: 221-248. DOI: 10.1146/annurev.physiol.69.031905.160725
[2] MARGARITA GARCIA-CALVO. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005: 8132-8137. DOI: 10.1073/pnas.0500269102
[3] THOMAS SUDHOP K von B. Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia.[J]. Drugs, 2002, 62 16: 2333-2347. DOI: 10.2165/00003495-200262160-00002 |
| | EzetiMibe-d4 Preparation Products And Raw materials |
|