2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide

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2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Basic information
Product Name:2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide
Synonyms:(4S)-6-(4-Chlorophenyl)-1-methyl-4H-isoxazolo[5,4-d][2]benzazepine-4-acetamide;CPI0160;2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide;2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide;4H-Isoxazolo[5,4-d][2]benzazepine-4-acetamide, 6-(4-chlorophenyl)-1-methyl-, (4S)-;0610;Pelabresib (CPI-0610);CP1-0610
CAS:1380087-89-7
MF:C20H16ClN3O2
MW:365.81
EINECS:
Product Categories:Inhibitors
Mol File:1380087-89-7.mol
2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Structure
2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Chemical Properties
Boiling point 622.8±55.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (273.37 mM; Need ultrasonic)
form Powder
pka16.07±0.40(Predicted)
color White to off-white
InChIInChI=1S/C20H16ClN3O2/c1-11-18-14-4-2-3-5-15(14)19(12-6-8-13(21)9-7-12)23-16(10-17(22)25)20(18)26-24-11/h2-9,16H,10H2,1H3,(H2,22,25)/t16-/m0/s1
InChIKeyGCWIQUVXWZWCLE-INIZCTEOSA-N
SMILESN1=C(C2=CC=C(Cl)C=C2)C2=CC=CC=C2C2C(C)=NOC=2[C@@H]1CC(N)=O
Safety Information
MSDS Information
2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Usage And Synthesis
UsesBET Bromodomain Inhibitor has be shown to inhibit myeloma cell proliferation in clinically relevant models.
in vivo

Pelabresib (30-60 mg/kg; oral administration; for 28 days; MV-4-11 mouse xenograft model) treatment results in substantial suppression of tumor growth over the time period examined (41%, 80%, and 74% tumor growth inhibition, respectively), without any significant body weight loss in the animals[1].

Animal Model:MV-4-11 mouse xenograft model[1]
Dosage:30 mg/kg once daily, 30 mg/kg twice daily, or 60 mg/kg once daily
Administration:Oral administration; for 28 days
Result:Suppressed of tumor growth, without any significant body weight loss in the animals.
IC 50BRD4-BD1: 39 nM (IC50)
2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide Preparation Products And Raw materials
Tag:2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide(1380087-89-7) Related Product Information
4H-Isoxazolo[5,4-d][2]benzazepine-4-acetic acid, 6-(4-chlorophenyl)-1-methyl-, (4S)- BET bromodomain inhibitor CPI-268456 2-[6-(4-Chloro-phenyl)-1-Methyl-4H-3-oxa-2,5-diaza-benzo[e]azulen-4-yl]-acetaMide 6-pentadecylsalicylic acid Anti-cancer compound library Bet Bromodomain Inhibitor