6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one

6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one Suppliers list

Company Name:	Energy Chemical
Tel:	021-58432009 400-005-6266
Email:	marketing@energy-chemical.com

6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one Basic information

Product Name:	6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one
Synonyms:	6-B345TTQ;6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one;Benzo[h]quinolin-2(1H)-one, 6-bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-;6-B345TTQ >98% (HPLC)
CAS:	297157-87-0
MF:	C22H20BrNO4
MW:	442.3
EINECS:
Product Categories:
Mol File:	297157-87-0.mol

6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one Chemical Properties

storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
form	powder
color	white to off-white
InChI	1S/C22H20BrNO4/c1-26-18-8-12(9-19(27-2)22(18)28-3)15-11-20(25)24-21-14-7-5-4-6-13(14)17(23)10-16(15)21/h4-10,15H,11H2,1-3H3,(H,24,25)
InChIKey	KPOXOTVERMGJQS-UHFFFAOYSA-N
SMILES	COc1cc(cc(OC)c1OC)C2CC(=O)Nc3c2cc(Br)c4ccccc34

Safety Information

Hazard Codes	N
Risk Statements	50
Safety Statements	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Acute 1 Aquatic Chronic 1

MSDS Information

6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one Usage And Synthesis

Uses	6-B345TTQ is an α4 integrin inhibitor that inhibits α4-Leupaxin interaction. 6-B345TTQ can be used in inflammation research[1].
Biological Activity	6-B345TTQ is a non-cytotoxic inhibitor of α4 integrin paxillin interaction.
References	[1] Kummer C, et al. A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem. 2010 Mar 26;285(13):9462-9469. DOI:10.1074/jbc.M109.066993

6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one Preparation Products And Raw materials

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