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2'-Azido-2'-deoxy-5-methylcytidine manufacturers
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| | 2'-Azido-2'-deoxy-5-methylcytidine Basic information |
| Product Name: | 2'-Azido-2'-deoxy-5-methylcytidine | | Synonyms: | 2'-Azido-2'-deoxy-5-methylcytidine;2’-Azido-2’-deoxy-5-methylcytidine;4-amino-1-((2R,3R,4S,5R)-3-azido-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidin-2(1H)-one | | CAS: | 2095417-75-5 | | MF: | C10H14N6O4 | | MW: | 282.26 | | EINECS: | | | Product Categories: | | | Mol File: | 2095417-75-5.mol |  |
| | 2'-Azido-2'-deoxy-5-methylcytidine Chemical Properties |
| | 2'-Azido-2'-deoxy-5-methylcytidine Usage And Synthesis |
| Uses | 2’-Azido-2’-deoxy-5-methyl cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2’-Azido-2’-deoxy-5-methyl cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | References | [1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
| | 2'-Azido-2'-deoxy-5-methylcytidine Preparation Products And Raw materials |
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