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| | Trityl-PEG9-Azide Basic information |
| Product Name: | Trityl-PEG9-Azide | | Synonyms: | Trityl-PEG9-Azide;Trityl-PEG10-Azide;Trityl-PEG9-N3;2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontane,31-azido-1,1,1-triphenyl-;31-Azido-1,1,1-triphenyl-2,5,8,11,14,17,20,23,26,29-decaoxahentriacontane | | CAS: | 877239-08-2 | | MF: | C39H55N3O10 | | MW: | 725.88 | | EINECS: | | | Product Categories: | peg | | Mol File: | 877239-08-2.mol |  |
| | Trityl-PEG9-Azide Chemical Properties |
| | Trityl-PEG9-Azide Usage And Synthesis |
| Description | Trityl-PEG10-azide is a PEG linker containing an azide group and a trityl protected ester. Trityl group can be removed under acid conditions or hydrogenolysis. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Trityl-PEG10-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Trityl-PEG10-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Trityl-PEG9-Azide Preparation Products And Raw materials |
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