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| | COX-2 INHIBITOR I Basic information |
| Product Name: | COX-2 INHIBITOR I | | Synonyms: | METHYL [5-METHYLSULFONYL-1-(4-CHLOROBENZYL)-1H-2-INDOLYL]CARBOXYLATE;LM-1685;COX-2 INHIBITOR I;1H-Indole-2-carboxylic acid, 1-[(4-chlorophenyl)methyl]-5-(methylsulfonyl)-, methyl ester | | CAS: | 416901-58-1 | | MF: | C18H16ClNO4S | | MW: | 377.84 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | COX-2 INHIBITOR I Chemical Properties |
| Melting point | 177-179 °C | | Boiling point | 604.3±55.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | methanol: 1mg/mL
DMSO: 100mg/mL | | form | solid | | color | white |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | COX-2 INHIBITOR I Usage And Synthesis |
| Uses | COX-2-IN-5 (compound 11a) is a potent COX-2 inhibitor with an IC50 value of 0.65 μM. COX-2-IN-5 has the potential for the research of inflammation[1]. | | Definition | ChEBI: LM-1685 is an indolyl carboxylate ester that is methyl 1H-indole-2-carboxylate substituted by a 4-chlorobenzyl group at position 1 and a methylsulfonyl group at position 5. It acts as a selective inhibitor of cyclooxygenase 2. It has a role as a cyclooxygenase 2 inhibitor. It is an indolyl carboxylate ester, a sulfone, a member of monochlorobenzenes and a methyl ester. | | Biological Activity | Cell permeable: yes', 'Primary Target
COX-2 from human monocytes', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 650 nM against COX-2 from human monocytes; 4.3 μM against COX-2 in whole blood | | IC 50 | COX-2: 0.65 μM (IC50) | | References | [1] Palomer A, et al. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem. 2002 Mar 28;45(7):1402-11. DOI:10.1021/jm010458r |
| | COX-2 INHIBITOR I Preparation Products And Raw materials |
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