FIT-039 manufacturers
- FIT-039
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- $31.00
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2026-07-27
- CAS:1113044-49-7
- Purity: 99.39%
- Supply Ability: 10g
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| | FIT-039 Basic information |
| Product Name: | FIT-039 | | Synonyms: | FIT-039;FIT-039
(FIT039);4-Pyridinecarbothioamide, N-[5-fluoro-2-(1-piperidinyl)phenyl]-;N-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide;N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide;Cytomegalovirus,HSV-1,Herpes simplex virus,transcription,Inhibitor,DNA,CDK,Cyclin dependent kinase,CDK9,CMV,FIT 039,mRNA,FIT039,viruses,antiviral,inhibit,orally,FIT-039,polymerase-II,HSV-2,DNA/RNA Synthesis,HSV;FIT-039, 10 mM in DMSO;KP-1115 | | CAS: | 1113044-49-7 | | MF: | C17H18FN3S | | MW: | 315.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1113044-49-7.mol |  |
| | FIT-039 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO:55.0(Max Conc. mg/mL);174.38(Max Conc. mM) | | form | A solid | | color | Light yellow to yellow | | InChIKey | VRKZHYSJZOUICG-UHFFFAOYSA-N | | SMILES | Fc1cc(c(cc1)N3CCCCC3)NC(=S)c2ccncc2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | FIT-039 Usage And Synthesis |
| Description | FIT-039 is a novel cyclin-dependent kinase 9 (CDK9) inhibitor, suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription. | | Uses | FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses. | | in vivo | Treatment with the FIT-039 ointment twice a day suppresses skin lesions and rescues mice (male BALB/c mice injected with HSV-1) from lethality in a dose-dependent manner. The healing of lesions is observed with 5% to 10% FIT-039 ointment, leading to the complete regression of zosteriform spread on day 10, which is also observed with the 5% ACV ointment[1].
FIT-039 does not affect body weight gain in mice administrated with an overdose of this compound (1000 mg/kg/d) for 14 days, and no changes are observed in biological markers in their blood[1]. | | target | FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. | | IC 50 | CDK9/cyclinT1: 5.8 μM (IC50); HSV-1: 0.69 μM (IC50); HSV-2; CMV | | References | [1] Makoto Yamamoto, et al. CDK9 Inhibitor FIT-039 Prevents Replication of Multiple DNA Viruses. J Clin Invest. 2014 Aug;124(8):3479-88. DOI:10.1172/JCI73805 |
| | FIT-039 Preparation Products And Raw materials |
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