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| | t-butyl acetate-PEG3-CH2COOH Basic information |
| Product Name: | t-butyl acetate-PEG3-CH2COOH | | Synonyms: | t-butyl acetate-PEG3-CH2COOH;HOOCCH2O-PEG3-CH2COOtBu;HOOCCH2O-PEG3-CH2COOtBu/3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester;3,6,9,12-Tetraoxatetradecanedioic acid, 1-(1,1-dimethylethyl) ester;COOtBu-CH2-PEG3-OCH2COOH;16,16-Dimethyl-14-oxo-3,6,9,12,15-pentaoxaheptadecanoic acid | | CAS: | 1442466-57-0 | | MF: | C14H26O8 | | MW: | 322.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1442466-57-0.mol |  |
| | t-butyl acetate-PEG3-CH2COOH Chemical Properties |
| Boiling point | 435.6±35.0 °C(Predicted) | | density | 1.138±0.06 g/cm3(Predicted) | | pka | 3.39±0.10(Predicted) |
| | t-butyl acetate-PEG3-CH2COOH Usage And Synthesis |
| Uses | t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | t-Butyl acetate-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | t-butyl acetate-PEG3-CH2COOH Preparation Products And Raw materials |
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