(±)16(17)-EpDPA

Request For Quotation
(±)16(17)-EpDPA Suppliers list
Company Name: Yichang Zhongyitai Trading Co., Ltd.  
Tel: 0717-6449896 13886658719
Email: root@zhongyitai.com
Company Name: Alfa Chemistry  
Tel: 1-516-6625404
Email: support@alfa-chemistry.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com

(±)16(17)-EpDPA manufacturers
(±)16(17)-EpDPA Basic information
Product Name:(±)16(17)-EpDPA
Synonyms:(±)16(17)-EpDPA;BCTXZWCPBLWCRV-QCAYAECISA-N;(±)16(17)-EpDPA MaxSpec Standard;4,7,10,13-Pentadecatetraenoic acid, 15-[(2R,3S)-3-(2Z)-2-penten-1-yl-2-oxiranyl]-, (4Z,7Z,10Z,13Z)-rel-;16,(17)-Epoxy-4(Z),7(Z),10(Z),13(Z),19(Z)-DPA
CAS:155073-46-4
MF:C22H32O3
MW:344.49
EINECS:
Product Categories:
Mol File:155073-46-4.mol
(±)16(17)-EpDPA Structure
(±)16(17)-EpDPA Chemical Properties
Boiling point 462.5±33.0 °C(Predicted)
density 0.994±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
pka4.58±0.10(Predicted)
Safety Information
MSDS Information
(±)16(17)-EpDPA Usage And Synthesis
DescriptionEDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.1,2 Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.3 However, the CYP450 metabolites of eicosapentaenoic acid (EPA; ) and docosahexaenoic acid (DHA; ) have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.4
Uses(±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA.
References1. Chataigneau, T., Félétou, M., Duhault, J., et al. Epoxyeicosatrienoic acids, potassium channel blockers, and endothelium-dependent hyperpolarization in the guinea-pig carotid artery Br. J. Pharmacol. 123(3),574-580(1998).
2. Fisslthaler, B., Popp, R., Kiss, L., et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries Nature 401(6752),493-497(1999).
3. Baron, A., Frieden, M., and Bény, J.L. Epoxyeicosatrienoic acids activate a high-conductance, Ca2+-dependent K+ channel on pig coronary artery endothelial cells J. Physiol. 504(Pt 3),537-543(1997).
4. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals J. Exp. Med. 196(8),1025-1037(2002).
(±)16(17)-EpDPA Preparation Products And Raw materials
Tag:(±)16(17)-EpDPA(155073-46-4) Related Product Information
(±)7(8)-EpDPA (±)10(11)-EpDPA (±)13(14)-EpDPA 4(5)-Epdpe methyl ester (19(20)-EpDPA N-Acetyl-D-Glucosamine