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P11 manufacturers
- P11
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- $198.00
-
2026-05-11
- CAS:942285-55-4
- Purity:
- Supply Ability: 10g
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| Product Name: | P11 | | Synonyms: | KUBDPRSHRVANQQ-NSOVKSMOSA-N;(2S,6S)-6-(4-tert-butylphenyl)-2-(4-methylphenyl)-1-(4-methylphenyl)sulfonyl-3,6-dihydro-2H-pyridine-5-carboxylic acid;PAFAH inhibitor P11;3 IN P11;3INP11;3-IN-P11;PAFAH1b2,PAFAH-1b2;3-Pyridinecarboxylic acid, 2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-, (2R,6R)-rel- | | CAS: | 942285-55-4 | | MF: | C30H33NO4S | | MW: | 503.65 | | EINECS: | | | Product Categories: | | | Mol File: | 942285-55-4.mol |  |
| Boiling point | 667.0±65.0 °C(Predicted) | | density | 1.210±0.06 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 4.02±0.60(Predicted) | | color | Light yellow to light brown |
| Description | PAFAH1b2 is a selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3. It acts by impairing cancer cell survival. | | Uses | P11 is a selective inhibitor of platelet-activating factor acetylhydrolases (PAFAHs) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC50 values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively[1]. | | References | [1] Jae Won Chang, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. ACS Chem Biol. 2015 Apr 17;10(4):925-32. DOI:10.1021/cb500893q |
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