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Leucettine L41 manufacturers
- Leucettine L41
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- $78.00
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2026-07-27
- CAS:1112978-84-3
- Purity: 99.08%
- Supply Ability: 10g
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| | Leucettine L41 Basic information |
| Product Name: | Leucettine L41 | | Synonyms: | Leucettine L41;4H-Imidazol-4-one, 5-(1,3-benzodioxol-5-ylmethylene)-3,5-dihydro-2-(phenylamino)-, (5Z)-;Leucettine L41,Leucettine L-41;(Z)-4-(Benzo[d][1,3]dioxol-5-ylmethylene)-2-(phenylamino)-1H-imidazol-5(4H)-one | | CAS: | 1112978-84-3 | | MF: | C17H13N3O3 | | MW: | 307.3 | | EINECS: | | | Product Categories: | | | Mol File: | 1112978-84-3.mol |  |
| | Leucettine L41 Chemical Properties |
| Melting point | >260 °C(Solvent: Ethanol) | | Boiling point | 475.009±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.419±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble; Ethanol: soluble | | form | A solid | | pka | -0.429±0.20(predicted) | | color | Light yellow to yellow |
| | Leucettine L41 Usage And Synthesis |
| Description | Leucettine L41 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively).1 It also inhibits GSK3α/β and Pim1 with IC50 values of 0.41 and 4.1 μM, respectively. It inhibits phosphorylation of the serine/arginine (SR) protein 9G8 by DYRK2, DYRK3, CLK1, CLK2, and CLK4 and inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells when used at concentrations ranging from 0.1 to 10 μM. Leucettine L41 modulates alternative pre-RNA splicing of a synthetic CLK1 minigene in a reporter model. It prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by amyloid-β 25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity.2 Leucettine L41 (0.4, 1.2, and 4 μg, i.c.v.) also prevents memory deficits induced by amyloid-β 25-35 in the same model. | | Uses | Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 μM, respectively)[1]. Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model[2]. | | References | 1. Debdab, M., Carreaux, F., Renault, S., et al. Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: Modulation of alternative pre-RNA splicing J. Med. Chem. 54(12),4172-4186(2011).
2. Naert, G., Ferré, V., Meunier, J., et al. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice Eur. Neuropsychopharmacol. 25(11),2170-2182(2015). |
| | Leucettine L41 Preparation Products And Raw materials |
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