海南冬青苷D
| 中文名称 | 海南冬青苷D |
|---|---|
| 中文同义词 | 海南冬青苷D;(3S,4R,4aR,6aR,6bS,8aR,12S,12aS,14aR,14bR)-3,12-二羟基-4,6a,6b,11,11,14b-六甲基-8a-((((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧)羰基)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-二十氢菲-4-羧酸;冬青叶苷D |
| 英文名称 | Ilexhainanoside D |
| 英文同义词 | Ilexhainanoside D;Olean-12-ene-23,28-dioic acid, 3,19-dihydroxy-, 28-β-D-glucopyranosyl ester, (3β,4β,19α)- |
| CAS号 | 1137648-52-2 |
| 分子式 | C36H56O11 |
| 分子量 | 664.83 |
| EINECS号 | |
| 相关类别 | 对照品;对照品 |
| Mol文件 | 1137648-52-2.mol |
| 结构式 |  |
海南冬青苷D 性质
| 沸点 | 788.1±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.47±0.70(Predicted) |
The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240 mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes / Bacteroidetes , reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia . The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines.