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| | PEG21-Tos Basic information |
| Product Name: | PEG21-Tos | | Synonyms: | PEG21-Tos;PEG20-Tos;3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-Nonadecaoxanonapentacontane-1,59-diol, 1-4-methylbenzenesulfonate;PEG21-Tosylate;OH-PEG20-Tos;OH-PEG20-OTs | | CAS: | 2179113-08-5 | | MF: | C47H88O23S | | MW: | 1053.25 | | EINECS: | | | Product Categories: | | | Mol File: | 2179113-08-5.mol |  |
| | PEG21-Tos Chemical Properties |
| Boiling point | 913.1±65.0 °C(Predicted) | | density | 1.149±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 14.36±0.10(Predicted) |
| | PEG21-Tos Usage And Synthesis |
| Description | PEG21-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | | Uses | PEG20-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | PEG21-Tos Preparation Products And Raw materials |
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