| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
Ospemifene-d4 manufacturers
- Ospemifene D4
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- $428.00
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2026-05-11
- CAS:
- Purity:
- Supply Ability: 10g
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| | Ospemifene-d4 Basic information |
| | Ospemifene-d4 Chemical Properties |
| solubility | Acetonitrile: soluble |
| | Ospemifene-d4 Usage And Synthesis |
| Description | Ospemifene-d4 is intended for use as an internal standard for the quantification of ospemifene (Item No. 23755) by GC- or LC-MS. Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).1 It binds to estrogen receptor α (ERα) and ERβ (Kis = 380 and 410 nM, respectively). It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits estrogen response element-mediated transactivation induced by 17β-estradiol (Item No. 10006315) in a reporter assay using MCF-7 cells. Formulations containing ospemifene have been used in the treatment of vulvar and vaginal atrophy-induced dyspareunia.WARNING This product is not for human or veterinary use. | | References | [1] MIKKO UNKILA . Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause[J]. Journal of Steroid Biochemistry and Molecular Biology, 2013, 138: Pages 107-115. DOI: 10.1016/j.jsbmb.2013.04.004 |
| | Ospemifene-d4 Preparation Products And Raw materials |
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