- PBT-1033
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- $30.00
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2026-06-02
- CAS:747408-78-2
- Purity: 98.12%
- Supply Ability: 10g
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| | 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Basic information |
| Product Name: | 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL | | Synonyms: | 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL;8-Quinolinol,5,7-dichloro-2-[(dimethylamino)methyl]-;PB 1033;5,7-Dichloro-2-((dimethylamino)methyl)quinolin-8-ol;PBT-1033, 10 mM in DMSO;5,7-Dichloro-2-[(dimethylamino)methyl]-8-quinolinol | | CAS: | 747408-78-2 | | MF: | C12H12Cl2N2O | | MW: | 271.14 | | EINECS: | | | Product Categories: | | | Mol File: | 747408-78-2.mol |  |
| | 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Chemical Properties |
| Boiling point | 367.8±37.0 °C(Predicted) | | density | 1.385±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (368.81 mM; Need ultrasonic) | | form | Solid | | pka | 7.26±0.28(Predicted) | | color | Light yellow to brown |
| | 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Usage And Synthesis |
| Uses | PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2]. | | in vivo | PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease[5].
| Animal Model: | Female Tg2576 mice[5] | | Dosage: | 30 mg/kg/d | | Administration: | Oral administration, 11 days | | Result: | Increased hippocampal apical spine density, basal spine density.
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| | References | [1] Faux NG, et al. PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20(2):509-16. DOI:10.3233/JAD-2010-1390
[2] Harbison-Price N, et al. Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2. mSphere. 2020 Mar 18;5(2):e00157-20.
[3] Johanssen T, et al. PBT2 inhibits glutamate-induced excitotoxicity in neurons through metal-mediated preconditioning. Neurobiol Dis. 2015 Sep;81:176-85. DOI:10.1016/j.nbd.2015.02.008
[4] Crouch PJ, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem. 2011 Oct;119(1):220-30. DOI:10.1111/j.1471-4159.2011.07402.x
[5] Adlard PA, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One. 2011 Mar 11;6(3):e17669. DOI:10.1371/journal.pone.0017669 |
| | 7-DICHLORO-2-DIMETHYLAMINOMETHYL-QUINOLIN-8-OL Preparation Products And Raw materials |
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