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- Chlorquinaldol
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2026-09-17
- CAS:72-80-0
- Min. Order: 1g
- Purity: More Than 99%
- Supply Ability: 100kg/Month
- Chlorquinaldol
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- $29.00
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2026-08-30
- CAS:72-80-0
- Purity: 98.22%
- Supply Ability: 10g
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| | 5,7-Dichloro-8-hydroxyquinaldine Basic information |
| | 5,7-Dichloro-8-hydroxyquinaldine Chemical Properties |
| Melting point | 108-112 °C (dec.)(lit.) | | Boiling point | 350.7±37.0 °C(Predicted) | | density | 1.3126 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO, Methaol (Slightly) | | form | Solid | | pka | 2.47±0.30(Predicted) | | color | Dark Beige to Very Dark Beige | | Water Solubility | Insoluble | | Merck | 13,2209 | | BRN | 156683 | | InChI | 1S/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3 | | InChIKey | GPTXWRGISTZRIO-UHFFFAOYSA-N | | SMILES | Cc1ccc2c(Cl)cc(Cl)c(O)c2n1 | | CAS DataBase Reference | 72-80-0(CAS DataBase Reference) | | NIST Chemistry Reference | Chlorquinaldol(72-80-0) |
| Hazard Codes | Xn,T | | Risk Statements | 22-36/37/38-23/24/25 | | Safety Statements | 26-36-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | VC5600000 | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 5,7-Dichloro-8-hydroxyquinaldine Usage And Synthesis |
| Chemical Properties | yellowish to beige-brown powder | | Originator | Sterosan ,Geigy ,US ,1954 | | Uses | Chlorquinaldol is a fungistat and antibacterial agent in topical pharmaceutical preparations (5,7-dichloro-2-methyl-8-quinolinol, Sterosan). | | Uses | antiinfectant, antifungal | | Uses | 5,7-Dichloro-8-hydroxy-2-methylquinoline is an anti-infective agent. | | Definition | ChEBI: A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections. | | Manufacturing Process | 11.1 parts of 8-hydroxy-quinaldine are dissolved in 140 parts of formic acid.
Chlorine is introduced into this solution under cooling, until the increase in
weight corresponds to the required quantity of chlorine and a test of the
chlorination mixtures gives no more dyestuff formation with diazo-benzene in
an acetic acid solution
When the chlorination is complete, the reaction mixture is poured into 1,000
parts of water and treated with a dilute sodium bisulfite solution, until no
more reaction may be observed with starch potassium iodide paper. Thereby
the 5,7-dichloro-8-hydroxy-quinaldine separates out in form of a weakly
yellowish colored precipitate. The same is filtered off and thoroughly washed
with water.After drying, 15 parts of 5,7-dichloro-8-hydroxy-quinaldine melting at 111°C
to 112°C are obtained. When recrystallized from alcohol, the product is
obtained in voluminous, slightly yellowish needles having the melting point of
111.5°C to 112°C. | | Therapeutic Function | Antibacterial | | Purification Methods | Crystallise it from EtOH. [Beilstein 21/3 V 346.] | | References | [1] Patent: CN108341776, 2018, A. Location in patent: Paragraph 0018-0032
[2] Patent: CH229982, 1942,
[3] Patent: CH245365, 1944,
[4] Patent: CN106966971, 2017, A. Location in patent: Paragraph 0029; 0030
[5] Patent: CN107089944, 2017, A. Location in patent: Paragraph 0028; 0029 |
| | 5,7-Dichloro-8-hydroxyquinaldine Preparation Products And Raw materials |
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