2,3-BIS(BROMOMETHYL)QUINOXALINE manufacturers
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| | 2,3-BIS(BROMOMETHYL)QUINOXALINE Basic information |
| Product Name: | 2,3-BIS(BROMOMETHYL)QUINOXALINE | | Synonyms: | 2,3-BIS(BROMOMETHYL)QUINOXALINE;2,3-BIS-(BROMETHYL)-QUINOXALINE98%;2,3-bis(bromomethyl)-quinoxalin;2,3-Bis-(bromomethyl)quinoxaline, HPLC 98%;2,3-Bis(bromomethyl)quinoxaline,98%;2,3-Bis(bromomethyl)-1,4-benzodiazine;NSC 38602;2,3-BIS-(BROMETHYL)QUINOXALINE | | CAS: | 3138-86-1 | | MF: | C10H8Br2N2 | | MW: | 315.99 | | EINECS: | 221-538-4 | | Product Categories: | Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinoxalines;QuinoxalinesHeterocyclic Building Blocks | | Mol File: | 3138-86-1.mol |  |
| | 2,3-BIS(BROMOMETHYL)QUINOXALINE Chemical Properties |
| Melting point | 152-156 °C(lit.) | | Boiling point | 345.7±37.0 °C(Predicted) | | density | 1.7904 (rough estimate) | | refractive index | 1.7040 (estimate) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder | | pka | -1.31±0.48(Predicted) | | Appearance | Off-white to gray Solid | | EPA Substance Registry System | Quinoxaline, 2,3-bis(bromomethyl)- (3138-86-1) |
| Hazard Codes | C | | Risk Statements | 34-36/37 | | Safety Statements | 26-27-28-36/37/39-45 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | RTECS | VD1420000 | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | Toxicity | LD50 ivn-mus: 18 mg/kg CSLNX* NX#02400 |
| | 2,3-BIS(BROMOMETHYL)QUINOXALINE Usage And Synthesis |
| Chemical Properties | grey to beige-brown crystalline powder | | Safety Profile | Poison by intravenous route. Seealso BROMIDES. When heated to decomposition it emitsvery toxic fumes of Br- and NOx. | | Synthesis | The general procedure for the synthesis of 2,3-bis(bromomethyl)quinoxaline from o-phenylenediamine and 1,4-dibromo-2,3-butanedione was as follows: 6.52 g (27 mmol) of 1,4-dibromo-2,3-butanedione and 300 mL of ethanol were added to a 1,000 mL three-neck flask. Subsequently, a solution made from 2.94 g (27 mmol) of o-phenylenediamine dissolved in 150 mL of ethanol was added to the mixture with continuous stirring for 30 minutes at room temperature. White solid precipitation was observed during the reaction. To the reaction mixture, 200 mL of water was added and the white solid was collected by filtration and dried under reduced pressure to give 6.74 g (yield: 81%) of the target product 2,3-bis(bromomethyl)quinoxaline. The 1H nuclear magnetic resonance (1H-NMR) spectral data of the compound were as follows: 1H-NMR (CDCl3): δ 4.93 (s, 4H), 7.81 (q, 2H), 8.08 (q, 2H). | | References | [1] Tetrahedron, 2013, vol. 69, # 4, p. 1403 - 1416
[2] Journal of Organic Chemistry, 2005, vol. 70, # 13, p. 5055 - 5061
[3] Organometallics, 2013, vol. 32, # 12, p. 3493 - 3501
[4] Synthetic Communications, 2011, vol. 41, # 3, p. 417 - 425
[5] Journal of Chemical Crystallography, 2006, vol. 36, # 3, p. 211 - 215 |
| | 2,3-BIS(BROMOMETHYL)QUINOXALINE Preparation Products And Raw materials |
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