Acetic acid, [2-(phenylmethoxy)ethoxy]-

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Acetic acid, [2-(phenylmethoxy)ethoxy]- Basic information
Product Name:Acetic acid, [2-(phenylmethoxy)ethoxy]-
Synonyms:[2-(Benzyloxy)ethoxy]acetic acid;Acetic acid, [2-(phenylmethoxy)ethoxy]-;BnO-PEG1-CH2COOH;2-(2-(benzyloxy)ethoxy)acetic acid;BnO-PEG1-CH2COOH/Acetic acid, 2-[2-(phenylmethoxy)ethoxy]-;Acetic acid, 2-[2-(phenylmethoxy)ethoxy]-;2-(2-(Benzyloxy)ethoxy)acetic acid , BnO-PEG1-CH2COOH
CAS:93206-09-8
MF:C11H14O4
MW:210.22646
EINECS:
Product Categories:
Mol File:93206-09-8.mol
Acetic acid, [2-(phenylmethoxy)ethoxy]- Structure
Acetic acid, [2-(phenylmethoxy)ethoxy]- Chemical Properties
Boiling point 372.2±22.0 °C(Predicted)
density 1.173±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
form Liquid
pka3.40±0.10(Predicted)
color Colorless to light yellow
Safety Information
HS Code 2918999090
MSDS Information
Acetic acid, [2-(phenylmethoxy)ethoxy]- Usage And Synthesis
DescriptionBenzyl-PEG2-CH2CO2H is a PEG linker with a benzyl protecting group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis. The hydrophilic PEG linker increases the water solubility of the compound.
UsesBnO-PEG1-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
IC 50PEGs
References[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74
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