2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-

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2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- Basic information
Product Name:2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-
Synonyms:2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-;AZD 4407;ZD 4407;5-((4-((2S,4R)-4-hydroxy-2-methyltetrahydro-2H-pyran-4-yl)thiophen-2-yl)thio)-1-methylindolin-2-one
CAS:166882-70-8
MF:C19H21NO3S2
MW:375.5
EINECS:
Product Categories:
Mol File:166882-70-8.mol
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- Structure
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- Chemical Properties
Boiling point 665.6±55.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka13.68±0.40(Predicted)
Safety Information
MSDS Information
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- Usage And Synthesis
UsesAZD 4407 is a potent 5-lipoxygenase inhibitor.
IC 505-Lipoxygenase
References[1] Jonathan Hutton, et al. Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407. Org Process Res Dev. 1997 Jan 15;1(1): 61–67.
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- Preparation Products And Raw materials
Raw materials2H-Pyran-4-ol, tetrahydro-4-(5-mercapto-3-thienyl)-2-methyl-, (2S-trans)- (9CI)-->5-Bromo-1-methyl-2-oxoindoline-->Tetrakis(triphenylphosphine)palladium
Tag:2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-(166882-70-8) Related Product Information