166882-70-8
| 中文名称 | 166882-70-8 |
|---|---|
| 中文同义词 | 化合物 T10438;化合物 AZD 4407 |
| 英文名称 | 2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]- |
| 英文同义词 | 2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]-;AZD 4407;ZD 4407;5-((4-((2S,4R)-4-hydroxy-2-methyltetrahydro-2H-pyran-4-yl)thiophen-2-yl)thio)-1-methylindolin-2-one |
| CAS号 | 166882-70-8 |
| 分子式 | C19H21NO3S2 |
| 分子量 | 375.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 166882-70-8.mol |
| 结构式 |  |
166882-70-8 性质
| 沸点 | 665.6±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.38±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 13.68±0.40(Predicted) |
AZD 4407 是一种有效的 5-脂氧合酶 (5-lipoxygenase) 抑制剂。
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5-Lipoxygenase
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In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407).