N3-PEG4-CHO manufacturers
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| | N3-PEG4-CHO Basic information |
| Product Name: | N3-PEG4-CHO | | Synonyms: | N3-PEG4-ALD;N3-PEG4-CHO;Ald-PEG4-azide;Ald-C2-PEG4-azide;N3-PEG4-CH2CH2CHO;N3-PEG4-pALD | | CAS: | 2030118-14-8 | | MF: | C11H21N3O5 | | MW: | 275.31 | | EINECS: | | | Product Categories: | peg | | Mol File: | 2030118-14-8.mol |  |
| | N3-PEG4-CHO Chemical Properties |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| | N3-PEG4-CHO Usage And Synthesis |
| Description | Ald-PEG4-azide is a PEG linker with an aldehyde and azide end groups. Aldehyde is reactive toward hydrazide and aminooxy groups The azide group can react with alkynes, DBCO and BCN for copper-catalyzed Click Chemistry reactions. PEG linker increases the water solubility of the compound. | | Uses | Ald-C2-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Ald-C2-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N3-PEG4-CHO Preparation Products And Raw materials |
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