m-PEG3-4-nitrophenyl carbonate

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m-PEG3-4-nitrophenyl carbonate Basic information
Product Name:m-PEG3-4-nitrophenyl carbonate
Synonyms:m-PEG3-4-nitrophenyl carbonate;m-PEG2-4-nitrophenyl carbonate;2-(2-methoxyethoxy)ethyl (4-nitrophenyl) carbonate;Carbonic acid, 2-(2-methoxyethoxy)ethyl 4-nitrophenyl ester
CAS:105108-59-6
MF:C12H15NO7
MW:285.25
EINECS:
Product Categories:
Mol File:105108-59-6.mol
m-PEG3-4-nitrophenyl carbonate Structure
m-PEG3-4-nitrophenyl carbonate Chemical Properties
Boiling point 414.3±45.0 °C(Predicted)
density 1.273±0.06 g/cm3(Predicted)
form Liquid
color Light yellow to yellow
Safety Information
MSDS Information
m-PEG3-4-nitrophenyl carbonate Usage And Synthesis
Descriptionm-PEG3-4-nitrophenyl carbonate is a PEG linker with a nitrophenyl carbonate moiety. NPC is reactive towards the amino group of lysine by means of stable urethane linkages. The hydrophilic PEG linker increases the water solubility of the compound.
Usesm-PEG2-4-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50PEGs; Alkyl/ether
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
m-PEG3-4-nitrophenyl carbonate Preparation Products And Raw materials
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