N-(Amino-PEG4)-N-Biotin-PEG4-acid manufacturers
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| | N-(Amino-PEG4)-N-Biotin-PEG4-acid Basic information |
| Product Name: | N-(Amino-PEG4)-N-Biotin-PEG4-acid | | Synonyms: | N-(Amino-PEG4)-N-Biotin-PEG4-acid;4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 16-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-21-[(3aR,4R,6aS)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-, rel- | | CAS: | 2100306-84-9 | | MF: | C31H58N4O12S | | MW: | 710.88 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-84-9.mol |  |
| | N-(Amino-PEG4)-N-Biotin-PEG4-acid Chemical Properties |
| Boiling point | 861.058±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.188±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Soluble in Water, DMSO, DMF | | pka | 4.275±0.10(predicted) |
| | N-(Amino-PEG4)-N-Biotin-PEG4-acid Usage And Synthesis |
| Description | N-(Amino-PEG4)-N-Biotin-PEG4-acid is a 3-arm biotinylation reagent with terminal amine(NH2) and carboxylic acid moieties. The amine group can react with activated NHS esters. Carboxylic acid can conjugate with primary amines in the presence of activators such as EDC or HATU to form stable amide bonds. | | Uses | N-(Amino-PEG4)-N-Biotin-PEG4-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329 |
| | N-(Amino-PEG4)-N-Biotin-PEG4-acid Preparation Products And Raw materials |
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