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| | Coumatetralyl Basic information |
| | Coumatetralyl Chemical Properties |
| Melting point | 172-176 °C | | Boiling point | 374.26°C (rough estimate) | | density | 1.2251 (rough estimate) | | refractive index | 1.4200 (estimate) | | Fp | 100 °C | | storage temp. | 0-6°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 4.50±1.00(Predicted) | | Henry's Law Constant | 1.7×108 mol/(m3Pa) at 25℃, HSDB (2015) | | Major Application | agriculture
environmental | | InChI | 1S/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2 | | InChIKey | ULSLJYXHZDTLQK-UHFFFAOYSA-N | | SMILES | OC1=C(C2CCCc3ccccc23)C(=O)Oc4ccccc14 | | CAS DataBase Reference | 5836-29-3(CAS DataBase Reference) | | NIST Chemistry Reference | 2H-1-benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-(5836-29-3) | | EPA Substance Registry System | Coumatetralyl (5836-29-3) |
| Hazard Codes | T+ | | Risk Statements | 27/28-48/24/25-52/53 | | Safety Statements | 28-36/37-45-61 | | RIDADR | 3027 | | WGK Germany | 3 | | RTECS | GN7630000 | | HazardClass | 6.1(a) | | PackingGroup | II | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Acute Tox. 3 Dermal
Aquatic Chronic 1
Repr. 1B
STOT RE 1 | | Hazardous Substances Data | 5836-29-3(Hazardous Substances Data) |
| | Coumatetralyl Usage And Synthesis |
| Description | Coumatetralyl, is also called 4-hydroxy-3-(1,2,3,4-
tetrahydro-1-naphthyl)coumarin, consists of colorless crystals which are
slightly soluble in water (pH 7), benzene, toluene, diethyl
ether, readily soluble in dimethylformamide, dichloromethane,
isopropanol, soluble in alcohols, acetone.
Coumatetralyl is produced by the condensation of 4-
hydroxycoumarin with 1,2,3,4-tetrahydro-1-naphthol (28).
First introduced in 1956, coumatetralyl is one of the
most widely used first-generation anticoagulants. It is not,
however, available in the United States. | | Chemical Properties | Coumatetralyl is a yellowish-white, crystalline solid. | | Uses | Coumatetralyl is used as an anticoagulant rodenticide. Coumatetralyl is widely used to control rodent populations. | | Definition | ChEBI: Coumatetralyl is a hydroxycoumarin. | | Production Methods | Coumatetralyl is commercially synthesised through a condensation reaction between 4-hydroxycoumarin and 1-tetralonyl ketone. This process typically occurs in the presence of a base such as sodium hydroxide and a solvent like ethanol or acetic acid under controlled temperature conditions. The reaction yields coumatetralyl, which is then purified through crystallisation and drying to produce a stable, active compound. | | General Description | Yellowish-white crystalline powder; colorless when pure; odorless. Coumatetralyl is used as a rodenticide, functioning as an anticoagulant that does not induce bait-shyness. | | Reactivity Profile | Ketones, such as Coumatetralyl, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4. | | Health Hazard | Overdosage with anticoagulants may cause acute bleeding. Pre-existing blood clotting disease or liver disease may be aggravated by exposure. | | Fire Hazard | (Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Coumatetralyl may burn but does not ignite readily. Fire and runoff from fire control water may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Container may explode in heat of fire. Enolic form of compound has acidic properties and can form salts with metals. | | Agricultural Uses | Rodenticide: Coumatetralyl is used for rat control and functions
as an anticoagulant, of the warfarin type, that does not induce bait-shyness. Not approved for use in EU countries or
the U.S. There are 17 global suppliers. | | Trade name | BAY® 25634; BAY ENE® 11183B;
BAYER® 25,634; ENDOX®; ENDROCID®;
ENDROCIDE®; RACUMIN®; RAUCUMIN® 57;
RODENTIN® | | Mechanism of action | 1st generation anticoagulant, blocks formation of prothrombin, inhibits blood coagulation causing death by internal haemorrhage | | Potential Exposure | Coumatetralyl is used as a rodenticide, functioning as an anticoagulant that does not induce baitshyness. | | First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility. Whenthis chemical has been swallowed, get medical attention.Give large quantities of water and induce vomiting. Do notmake an unconscious person vomit. Medical observation isrecommended for 24-36 h following overexposure, aseffects may be delayed. | | storage | Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers | | Shipping | UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. | | Toxicity evaluation | The acute toxicity
for Norway rats is given as high but, as with many of these compounds, coumatetralyl is more potent when administered
in consecutive daily doses. No satisfactory data are
available on the acute oral toxicity of the compound to mice.
However, a complete kill of mice was obtained in the laboratory
following 21 days of feeding on coumatetralyl bait (29).
Proprietary baits generally carry 0.375% coumatetralyl.
Powder concentrates are available (strength 0.75%) which
are used for the preparation of poisoned baits and as a
tracking dust (18). | | Incompatibilities | Contact with oxidizers may cause fire and explosion hazard. Keep away from metals. | | Waste Disposal | Dissolve in a solvent and burn in a furnace by spraying in the solution | | Pesticide Type | Rodenticide |
| | Coumatetralyl Preparation Products And Raw materials |
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