AZ82 manufacturers
- AZ82
-
- $99.00
-
2026-07-14
- CAS:1449578-65-7
- Purity: 99.31%
- Supply Ability: 10g
- AZ82
-
- $99.00
-
2026-07-14
- CAS:1449578-65-7
- Purity: 99.31%
- Supply Ability: 10g
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| Product Name: | AZ82 | | Synonyms: | 5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide;AZ82;KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem;KIFC1 inhibitor AZ82;3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-;AZ82,AZ-82 | | CAS: | 1449578-65-7 | | MF: | C28H31F3N4O3S | | MW: | 560.63 | | EINECS: | | | Product Categories: | | | Mol File: | 1449578-65-7.mol |  |
| Boiling point | 707.9±60.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | +2C to +8C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | | form | Yellow film | | pka | 13.25±0.46(Predicted) | | color | White to off-white |
| WGK Germany | WGK 3 | | Storage Class | 13 - Non Combustible Solids |
| Uses | AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. | | Biological Activity | Cell permeable: yes', 'Primary Target
MT/KIFC1', 'Reversible: yes | | IC 50 | HSET/KIFC1: 300 nM (IC50); HSET/KIFC1: 43 nM (Ki) | | References | [1] Godinho SA, et al. Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). DOI:10.1098/rstb.2013.0467
[2] Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8. DOI:10.1021/cb400186w |
| | AZ82 Preparation Products And Raw materials |
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